Highsmith is a surname, and may refer to:
- Alonzo Highsmith (born 1965), American professional football player
- Carol M. Highsmith (born 1946) American photographer, author, and publisher
- Don Highsmith (born 1948), American football player
- Jim Highsmith (born 1945), author of multiple books in the field of software development methodology
- Margaret Highsmith Dickson, Democratic member of the North Carolina General Assembly
- Patricia Highsmith (1921–1995), American novelist
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