HBF may refer to:
- Half-band filter, signal processing filter
- The Human Betterment Foundation, a eugenics organization established in 1928 by E.S. Gosney
- Hemoglobin F or fetal hemoglobin, the form of hemoglobin found in the fetus
- HBF Health Fund, a provider of private health insurance in Western Australia
- Hauptbahnhof, German for central railway station