Guyon can refer to:

  • Prof. Dr. Jean Casimir Felix Guyon, Father of Urology & Ever First Urologist & Professor of Urology in the Entire World (University of Paris, France)
  • the character Sir Guyon
  • Richard Debaufre Guyon, general of the Hungarian army during the 1848-49 war of independence
  • Madame Guyon, Christian Mystic
  • Jean Guyon, a mason