Guyon can refer to:
- Prof. Dr. Jean Casimir Felix Guyon, Father of Urology & Ever First Urologist & Professor of Urology in the Entire World (University of Paris, France)
- the character Sir Guyon
- Richard Debaufre Guyon, general of the Hungarian army during the 1848-49 war of independence
- Madame Guyon, Christian Mystic
- Jean Guyon, a mason