Types
There are membrane-bound (type 1, guanylate cyclase-coupled receptor) and soluble (type 2, soluble guanylyl cyclase) forms of guanylyl cyclases.
Membrane bound guanylyl cyclases include an external ligand binding domain (e.g., for peptide hormones such as BNP and ANP), a transmembrane domain, and an internal catalytic domain homologous to adenate cyclases.
In the mammalian retina, two forms of guanylyl cyclase have been identified, each encoded by separate genes; RETGC-1 and RETGC-2 RETGC-1 has been found to be expressed in higher levels in cones compared to rod cells. Studies have also shown that mutations in the RETGC-1 gene can lead to cone-rod dystrophy by disrupting the phototransduction processes.
Read more about this topic: Guanylate Cyclase
Famous quotes containing the word types:
“He types his laboured column—weary drudge!
Senile fudge and solemn:
Spare, editor, to condemn
These dry leaves of his autumn.”
—Robertson Davies (b. 1913)
“The wider the range of possibilities we offer children, the more intense will be their motivations and the richer their experiences. We must widen the range of topics and goals, the types of situations we offer and their degree of structure, the kinds and combinations of resources and materials, and the possible interactions with things, peers, and adults.”
—Loris Malaguzzi (1920–1994)
“Our major universities are now stuck with an army of pedestrian, toadying careerists, Fifties types who wave around Sixties banners to conceal their record of ruthless, beaverlike tunneling to the top.”
—Camille Paglia (b. 1947)