Legal Status
In the United States, glycyrrhizin is classified as "generally recognized as safe" as a flavoring agent, although not as a sweetener. Glycyrrhizin is used as a flavoring in some candies, pharmaceuticals, and tobacco products.
The European Union suggests people should not consume any more than 100 mg of glycyrrhizic acid a day, equivalent to approximately 50 g of liquorice sweets.
In Japan, where concern over the safety of artificial sweeteners during the 1970s led to a shift towards plant-derived sugar substitutes, glycyrrhizin is a commonly used sweetener, often used in combination with another plant-based sweetener, stevia. However, the Japanese government has asked its citizens to limit their consumption to 200 milligrams per day.
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