Gist or GIST may refer to:
- Essence, the central idea or main substance
- GiST, or Generalized Search Tree, a flexible data structure for building search trees
- Gist (Computing), a scientific graphics library written in the C programming language
- Gist, a pastebin service operated by GitHub
- Gist processing, a cognitive process in fuzzy-trace theory
- Gastrointestinal stromal tumor, an uncommon neoplasm of the gastrointestinal tract
- German Institute of Science and Technology (Singapore), an R&D institute in Singapore
- Gwangju Institute of Science and Technology, an R&D university in Gwangju City, South Korea
- Mount Gist, a mountain 8 nautical miles (15 km) northwest of Mount Strathcona near the head of Denman Glacier
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