Mathematics
Consider a single gene locus with the alleles, which have the fitnesses and the allele frequencies respectively. Ignoring frequency-dependent selection, then genetic load may be calculated as:
where is the maximum value of the fitnesses and is mean fitness which is calculated as the mean of all the fitnesses weighted by their corresponding allele frequency:
where the allele is and has the fitness and frequency and respectively.
When the, then (1) simplifies to
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