In population genetics, genetic load or genetic burden is a measure of the cost of lost alleles due to selection (selectional load) or mutation (mutational load). It is a value in the range, where 0 represents no load. The concept was first formulated in 1937 by JBS Haldane, independently formulated, named and applied to humans in 1950 by H. J. Muller, and elaborated further by Haldane in 1957.
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Famous quotes containing the words genetic and/or load:
“What strikes many twin researchers now is not how much identical twins are alike, but rather how different they are, given the same genetic makeup....Multiples don’t walk around in lockstep, talking in unison, thinking identical thoughts. The bond for normal twins, whether they are identical or fraternal, is based on how they, as individuals who are keenly aware of the differences between them, learn to relate to one another.”
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“Rich are the sea-gods:Mwho gives gifts but they?
They grope the sea for pearls, but more than pearls:
They pluck Force thence, and give it to the wise.
Every wave is wealth to Daedalus,
Wealth to the cunning artist who can work
This matchless strength. Where shall he find, O waves!
A load your Atlas shoulders cannot lift?”
—Ralph Waldo Emerson (1803–1882)