GDC may refer to:
- Game Developers Conference, a popular annual video game conference
- Gadolinium-doped ceria, a ceramic electrolyte used in solid oxide fuel cells
- General Development Corporation
- General Dental Council
- Gross Dealer Concession
- Guglielmi Detachable Coil, a platinum coil commonly used for the occlusion of brain aneurysms.
- Society of Graphic Designers of Canada
- GDC, a D programming language front-end for the GNU Compiler Collection
- Virginia General District Court
- Gravity Discovery Center, Gingin, Western Australia