Gaudio is a surname. People with this surname include:
- Bob Gaudio (born 1942), a US-American singer
- Bob Gaudio (American football) (1925–2003), an American football player
- Dino Gaudio (born 1957), an American basketball coach
- Eugene Gaudio (1886–1920), a cinematographer and brother of Tony
- Gastón Gaudio (born 1978), an Argentinian tennis player
- Tony Gaudio (1883–1951), an Italian-American cinematographer and brother of Eugene
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