Families
In humans, 22 members of the FGF family have been identified, all of which are structurally related signaling molecules:
- Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). FGF1 is also known as acidic, and FGF2 is also known as basic fibroblast growth factor.
- Members FGF11, FGF12, FGF13, and FGF14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functional differences compared to the FGFs. Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs. This group is also known as "iFGF".
- Members FGF16 through FGF23 are newer and not as well characterized. FGF15 is the mouse ortholog of human FGF19 (hence there is no human FGF15).
- Human FGF20 was identified based on its homology to Xenopus FGF-20 (XFGF-20).
- In contrast to the local activity of the other FGFs, FGF15/FGF19, FGF21 and FGF23 have more systemic effects.
Read more about this topic: Fibroblast Growth Factor
Famous quotes containing the word families:
“What peaches and what penumbras! Whole families shopping at night!
Aisles full of husbands! Wives in the avocados, babies in the
tomatoes!—and you, Garcia Lorca, what were you doing down by
the watermelons?”
—Allen Ginsberg (b. 1926)
“It is ultimately in employers’ best interests to have their employees’ families functioning smoothly. In the long run, children who misbehave because they are inadequately supervised or marital partners who disapprove of their spouse’s work situation are productivity problems. Just as work affects parents and children, parents and children affect the workplace by influencing the employed parents’ morale, absenteeism, and productivity.”
—Ann C. Crouter (20th century)
“Happy or unhappy, families are all mysterious. We have only to imagine how differently we would be described—and will be, after our deaths—by each of the family members who believe they know us.”
—Gloria Steinem (b. 1934)