Families
In humans, 22 members of the FGF family have been identified, all of which are structurally related signaling molecules:
- Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). FGF1 is also known as acidic, and FGF2 is also known as basic fibroblast growth factor.
- Members FGF11, FGF12, FGF13, and FGF14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functional differences compared to the FGFs. Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs. This group is also known as "iFGF".
- Members FGF16 through FGF23 are newer and not as well characterized. FGF15 is the mouse ortholog of human FGF19 (hence there is no human FGF15).
- Human FGF20 was identified based on its homology to Xenopus FGF-20 (XFGF-20).
- In contrast to the local activity of the other FGFs, FGF15/FGF19, FGF21 and FGF23 have more systemic effects.
Read more about this topic: Fibroblast Growth Factor
Famous quotes containing the word families:
“We now recognize that abuse and neglect may be as frequent in nuclear families as love, protection, and commitment are in nonnuclear families.”
—David Elkind (20th century)
“Nostalgia is one of the great enemies of clear thinking about the family. The disruption of families in the nineteenth century through death, separation, and other convulsions of an industrializing economy was much more catastrophic than we imagine.”
—Joseph Featherstone (20th century)
“There is a city myth that country life was isolated and lonely; the truth is that farmers and their families then had a richer social life than they have now. They enjoyed a society organic, satisfying and whole, not mixed and thinned with the life of town, city and nation as it now is.”
—Rose Wilder Lane (1886–1965)