ERK can refer to:
- Extracellular signal-regulated kinases, a kind of protein molecule
Erk may refer to :
- Erk (party), a Muslim socialist organisation active in Bashkiria, Bukhara and Turkestan from 1919 to 1921
- Erk/Liberty Democratic Party, a political party in Uzbekistan
- Erk Russell, a former American football coach for Georgia Southern University
- Erk, an AC 2 or Aircraftsman, i.e. a Royal Air Force ground crew, in British slang
- Erk, a mage from Fire Emblem for the Game Boy Advance
- Edmund Frederick Erk (1872–1953), a Republican member of the U.S. House of Representatives from Pennsylvania
- Kutlay Erk, a former mayor of the Turkish Cypriot part of the capital of Cyprus, Nicosia
- South Efate language ISO 639-3 code, a language spoken on the island of Efate in central Vanuatu
- Efek Rumah Kaca, Indonesian indie band
- Uzbekistan Erk/Liberty Democratic Party, a political party in Uzbekistan (see Politics of Uzbekistan)