Clinical Significance
Because of the epigenetic effects of the DNMT family, some DNMT inhibitors are under investigation for treatment of some cancers :
- Vidaza (5-azacitidine) in a phase II trial for AML
- Dacogen (decitabine) in phase III trials for AML and CML
Read more about this topic: DNA Methyltransferase
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“I am not afraid that I shall exaggerate the value and significance of life, but that I shall not be up to the occasion which it is.”
—Henry David Thoreau (1817–1862)
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