O-6-methylguanine-DNA Methyltransferase

O-6-methylguanine-DNA Methyltransferase

Identifiers Symbol MGMT External IDs OMIM: 156569 MGI: 96977 HomoloGene: 31089 GeneCards: MGMT Gene EC number 2.1.1.63

Gene Ontology
Molecular function	• DNA binding • methylated-DNA- • calcium ion binding • methyltransferase activity • DNA-methyltransferase activity
Cellular component	• nucleus • nucleoplasm
Biological process	• DNA ligation • DNA repair • DNA methylation • DNA dealkylation involved in DNA repair • response to toxic substance • cellular response to oxidative stress • response to drug • regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to ethanol • positive regulation of DNA repair • response to folic acid • negative regulation of cell death • mammary gland epithelial cell differentiation • cellular response to organic cyclic compound • cellular response to ionizing radiation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4255 17314 Ensembl ENSG00000170430 ENSMUSG00000054612 UniProt P16455 P26187 RefSeq (mRNA) NM_002412 NM_008598 RefSeq (protein) NP_002403 NP_032624 Location (UCSC) Chr 10:
131.27 – 131.57 Mb Chr 7:
136.89 – 137.13 Mb PubMed search

O6-methylguanine-DNA methyltransferase is a protein that in humans is encoded by the MGMT gene.