Dimethyltryptamine - Side Effects

Side Effects

Similar to other psychedelic drugs, there are relatively few physical side effects associated with DMT acute exposure. When inhaled, its vapor has been described as "very harsh." According to a "Dose-response study of N,N-dimethyltryptamine in humans" by Rick Strassman, "Dimethyltryptamine dose slightly elevated blood pressure, heart rate, pupil diameter, and rectal temperature, in addition to elevating blood concentrations of beta-endorphin, corticotropin, cortisol, and prolactin. Growth hormone blood levels rose equally in response to all doses of DMT, and melatonin levels were unaffected."

Psychologically, the DMT experience can be overly-intense, potentially causing overwhelming fear and difficulty integrating experiences if one is not mentally prepared. Furthermore, due to the intense nature of the experience, DMT is generally considered to have no addiction potential. Just as with all psychedelics, there is a chance for an onset of paranoia, or a 'bad trip'. This risk is more prevalent with DMT, as DMT is more intense than normal psychedelics. Close attention should be paid to dose, set and setting. Also one should note that despite the lack of physical side effects, the intensity of the DMT experience could trigger latent mental illnesses in those who may have a genetic predisposition to such diseases.