The acronym DFB may refer to:
- Dysfunctional Family BBQ, an annual K-Rockathon event
- Dem Franchize Boyz, an American hip-hop group
- Dfb; humid continental climate under the Köppen climate classification system
- Distributed feedback laser, a diffraction laser system
- DFB Warehouse, an electronics distributor based in Nottingham, UK
- Dublin Fire Brigade, the local authority fire and rescue service for Dublin, Ireland
- Furka Heritage Railway (Dampfbahn Furka-Bergstrecke), a Swiss heritage railway
- German Football Association (Deutscher Fußball-Bund), the governing body of football in Germany