DEP is a three-letter acronym that can mean:
- Data Execution Prevention
- Delayed Entry Program
- Democracy Party, pro-Kurdish political party in Turkey
- Department of Environmental Protection
- Dielectrophoresis, the force exerted on a dielectric particle subjected to a non-uniform electric field
- Diethyl phthalate
- The Dillinger Escape Plan, a mathcore band
- DEP International, a defunct British record label founded by the band UB40
Dep can mean:
- Dep River, a river in Russia
- An ancient town in Egypt which merged with Pe to form Buto (formerly known as Per-Wadjet).
- Dépanneur, a convenience store in Quebec English