Darko is a common Slavic first name and also an Akan family name. It also can refer to:
People:
- Darko Miličić, basketball player
- Darko Planinić (born 1990), Croatian professional basketball player
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- See Darko (surname)
Miscellaneous:
- Donnie Darko, a 2001 film by Richard Kelly starring Jake Gyllenhaal and Jena Malone
- S. Darko, a 2009 film, sequel to Donnie Darko
- Darko AD, a Bulgarian ice cream company