Crusoe may refer to:
- Crusoe (TV series), a 2008 television series based on the novel Robinson Crusoe
- Crusoe (film), a 1989 film by Caleb Deschanel, based on the novel
- Transmeta Crusoe, a computer processor family by Transmeta Corporation
- The Water Horse: Legend of the Deep, a 2007 film featuring a creature named Crusoe
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