Chuk

Identifiers Symbols CHUK; IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16 External IDs OMIM: 600664 MGI: 99484 HomoloGene: 979 ChEMBL: 3476 GeneCards: CHUK Gene EC number 2.7.11.10

Gene Ontology
Molecular function	• protein kinase activity • protein binding • ATP binding • IkappaB kinase activity • identical protein binding
Cellular component	• nucleus • nucleolus • cytoplasm • cytosol • IkappaB kinase complex • internal side of plasma membrane • CD40 receptor complex • intracellular membrane-bounded organelle
Biological process	• morphogenesis of an epithelial sheet • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • protein phosphorylation • inflammatory response • immune response • epidermal growth factor receptor signaling pathway • I-kappaB kinase/NF-kappaB cascade • I-kappaB phosphorylation • lactation • Toll signaling pathway • fibroblast growth factor receptor signaling pathway • response to virus • anatomical structure morphogenesis • osteoclast differentiation • positive regulation of type I interferon production • mammary gland epithelial cell proliferation • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway • odontogenesis of dentin-containing tooth • positive regulation of I-kappaB kinase/NF-kappaB cascade • innate immune response • nerve growth factor receptor signaling pathway • phosphatidylinositol-mediated signaling • T cell receptor signaling pathway • positive regulation of NF-kappaB transcription factor activity • mammary gland alveolus development • nucleotide-binding oligomerization domain containing signaling pathway
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 1147 12675 Ensembl ENSG00000213341 ENSMUSG00000025199 UniProt O15111 Q60680 RefSeq (mRNA) NM_001278 NM_001162410 RefSeq (protein) NP_001269 NP_001155882 Location (UCSC) Chr 10:
101.95 – 101.99 Mb Chr 19:
44.07 – 44.11 Mb PubMed search

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.