CHS may refer to:
- Canadian Hemophilia Society, an organization in Canada representing people with inherited bleeding disorders, their friends and their families
- Canadian Hydrographic Service
- Center for Hellenic Studies, a research institute for classics affiliated with Harvard University
- Chalcone synthase, an enzyme associated with the production of chalcones in plants
- Charleston International Airport, Charleston, South Carolina, IATA airport code
- Cheshire, the Chapman code for that county in England
- Chungah, an obsolete unit of volume used in India
- CHS Inc., a United States energy and agricultural cooperative
- College Historical Society, The World's Oldest Student Society, based in Trinity College, Dublin
- Colorado Historical Society (aka History Colorado), the historical society of the US State of Colorado
- House Committee on Homeland Security
- Community Health Systems, Inc., a company that runs hospitals in the United States
- Contact Handling System, a software package used by the Metropolitan Police Service
- Connecticut Historical Society, the historical society of the US State of Connecticut
- Cylinder-head-sector, a method for addressing data on magnetic disks
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