Charles V may refer to:
- Charles V, Holy Roman Emperor (1500–1558), also Charles I of Spain
- Charles V of Naples (1661–1700), better known as Charles II of Spain
- Charles V of France (1338–1380), called the Wise
- Charles V, Duke of Lorraine (1643–1690)
- Infante Carlos of Spain, Count of Molina (1788–1855), first Carlist pretender to the throne of Spain (as Charles V)