CDH may refer to:
- Cloudera's Distribution Including Apache Hadoop, Cloudera's open-source Hadoop distribution.
- Campbell's dwarf hamster
- The Central DuPage Hospital in DuPage County, Illinois, U.S.A.
- Centre Démocrate Humaniste, a Belgian political party
- Chronic daily headache
- The Computational Diffie-Hellman assumption, indicating a certain level of hardness of a mathematical problem
- Congenital diaphragmatic hernia, a disorder involving abnormal development of the diaphragm
- Congenital dislocation of hip
- Consumer driven health care
- Cretin-Derham Hall, a private Catholic high school in St. Paul, Minnesota, U.S.A.
- The "Cross-Desert Highway" (Chinese: 塔里木沙漠公路) across the Taklamakan Desert of Central Asia.