Casino Royale may refer to:
- Casino Royale (novel), the first James Bond novel by Ian Fleming
- "Casino Royale" (Climax!), a 1954 television adaptation of Fleming's novel for the series Climax!
- Casino Royale (1967 film), a James Bond film parody starring David Niven and Peter Sellers
- Casino Royale (2006 film), a James Bond film starring Daniel Craig
- Casino Royale (2006 soundtrack)
- Casino Royale & Hotel, a hotel and casino on the strip in Las Vegas, United States
- Casino Royale, site of the 2011 Monterrey casino attack, a massacre that killed 52 in Mexico
- Casino Royale is a brand of casinos on the Royal Caribbean International cruise ships.