Calnexin

Identifiers Symbols CANX; CNX; IP90; P90 External IDs OMIM: 114217 MGI: 88261 HomoloGene: 1324 ChEMBL: 2719 GeneCards: CANX Gene

Gene Ontology
Molecular function	• calcium ion binding • protein binding • carbohydrate binding • unfolded protein binding
Cellular component	• endoplasmic reticulum • endoplasmic reticulum lumen • endoplasmic reticulum membrane • melanosome • integral to lumenal side of endoplasmic reticulum membrane
Biological process	• antigen processing and presentation of peptide antigen via MHC class I • protein folding • protein secretion • protein N-linked glycosylation via asparagine • antigen processing and presentation of exogenous peptide antigen via MHC class II • post-translational protein modification • cellular protein metabolic process • synaptic vesicle endocytosis • clathrin-mediated endocytosis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 821 12330 Ensembl ENSG00000127022 ENSMUSG00000020368 UniProt P27824 P35564 RefSeq (mRNA) NM_001024649.1 NM_001110499.1 RefSeq (protein) NP_001019820.1 NP_001103969.1 Location (UCSC) Chr 5:
179.11 – 179.16 Mb Chr 11:
50.29 – 50.33 Mb PubMed search

Calnexin (CNX) is a 67kDa integral protein (that appears variously as a 90kDa, 80kDa or 75kDa band on western blotting depending on the source of the antibody) of the endoplasmic reticulum (ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail.