BRU may stand for:
- IOC country code for Brunei
- IATA Code for Brussels Airport
- 5-Bromouracil, a brominated derivative of uracil
- Buller Rugby Football Union
- Bus Riders Union (Los Angeles), a civil rights organization in in Los Angeles, California
- Bus Riders Union (Vancouver), a non-profit organization in Vancouver, British Columbia
- Biserica Română Unită cu Roma, Greco-Catolică, the Romanian Church United with Rome, Greek-Catholic
- Begum Rokeya University, in Rangpur, Bangladesh