Apis may refer to:
- Advance Passenger Information System, a border control mechanism used by the United States, Korea, and other countries.
- Albastar Apis, motorglider
- Apis (god), an Egyptian god
- Apis (city), an Egyptian city
- Yamu, another Egyptian city, formerly called Apis
- Apis (genus), the genus of honeybees
- Apis (Greek mythology), a prophet in Greek mythology
- Apis (constellation), an obsolete constellation
- Dragutin Dimitrijević aka Apis - Head of Serbian Military Intelligence
- Aircraft Positioning and Information System, an aircraft docking guidance system.
- Wezel Apis 2, motorglider