Angleton refers to:
- Persons
- Doris Angleton (1951–1997), American socialite and murder victim from Texas
- James Jesus Angleton (1917–1987), American CIA official
- Robert Angleton (b. 1948), American bookmaker from Texas; accused then exonerated of the murder of his wife
- Roger Angleton (1942–1998), American murderer from Texas; killed Doris Angleton
- Places
- Angleton, Texas