Active Site
The active site consists of a zinc atom, His-67, Cys-174, Cys-46, Ser-48, His-51, Ile-269, Val-292, Ala-317, and Phe-319. The zinc coordinates the substrate(alcohol). The zinc is coordinated by Cys-46, Cys-174, and His-67. Phe-319, Ala-317, His-51, Ile-269 and Val-292 stabilize NAD+ by forming hydrogen bonds. His-51 and Ile-269 form hydrogen bonds with the alcohols on nicotinamide ribose. Phe-319, Ala-317 and Val-292 form hydrogen bonds with the amide on NAD+.
Read more about this topic: Alcohol Dehydrogenase
Famous quotes containing the words active and/or site:
“You need not be proud of me.... Im only being active till you can be againit isnt such a great desire on my part to serve the world and Ill fall back into habits of sloth quite easily!”
—Eleanor Roosevelt (18841962)
“It is not menstrual blood per se which disturbs the imaginationunstanchable as that red flood may bebut rather the albumen in the blood, the uterine shreds, placental jellyfish of the female sea. This is the chthonian matrix from which we rose. We have an evolutionary revulsion from slime, our site of biologic origins. Every month, it is womans fate to face the abyss of time and being, the abyss which is herself.”
—Camille Paglia (b. 1947)