Active Site
The active site consists of a zinc atom, His-67, Cys-174, Cys-46, Ser-48, His-51, Ile-269, Val-292, Ala-317, and Phe-319. The zinc coordinates the substrate(alcohol). The zinc is coordinated by Cys-46, Cys-174, and His-67. Phe-319, Ala-317, His-51, Ile-269 and Val-292 stabilize NAD+ by forming hydrogen bonds. His-51 and Ile-269 form hydrogen bonds with the alcohols on nicotinamide ribose. Phe-319, Ala-317 and Val-292 form hydrogen bonds with the amide on NAD+.
Read more about this topic: Alcohol Dehydrogenase
Famous quotes containing the words active and/or site:
“Things happen to us, all the time. It was like that for a century, and it is again. It’s not like here: People always do things, because you are born with it; you are brought up in this spirit, the active approach to life: “Stand up and go.” We were not. We were always passive in our lives.”
—Natasha Dudinska (b. c. 1967)
“The present hour is always wealthiest when it is poorer than the future ones, as that is the pleasantest site which affords the pleasantest prospects.”
—Henry David Thoreau (1817–1862)