Agouti-related Peptide

Agouti-related Peptide

Identifiers Symbols AGRP; AGRT; ASIP2; MGC118963; ART External IDs OMIM: 602311 MGI: 892013 HomoloGene: 7184 GeneCards: AGRP Gene

Gene Ontology
Molecular function	• receptor binding • neuropeptide hormone activity
Cellular component	• extracellular region
Biological process	• adult feeding behavior • neuropeptide signaling pathway • hormone-mediated signaling
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 181 11604 Ensembl ENSG00000159723 ENSMUSG00000005705 UniProt O00253 P56473 RefSeq (mRNA) NM_007316 NM_007427 RefSeq (protein) NP_001129 NP_031453 Location (UCSC) Chr 16:
66.07 – 66.08 Mb Chr 8:
108.09 – 108.09 Mb PubMed search

Agouti protein

Identifiers

Symbol

Agouti

Pfam

PF05039

Pfam clan

CL0083

InterPro

IPR007733

PROSITE

PDOC60024

SCOP

1hyk

SUPERFAMILY

1hyk

OPM protein

1mr0

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

Agouti-related protein also called Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only synthesised in NPY containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus. AgRP is co-expressed with Neuropeptide Y and works by increasing appetite and decreasing metabolism and energy expenditure. It is one of the most potent and long-lasting of appetite stimulators. In humans, the agouti-related peptide is encoded by the AGRP gene.

Read more about Agouti-related Peptide: Structure, Function, Mechanism, History, Role in Obesity, Human Proteins Containing This Domain