Structure
AgRP is a paracrine signalling molecule made up of 132 amino acids. It was independently identified by two teams in 1997 based on its sequence similarity with Agouti signalling peptide (ASIP), a protein synthesised in the skin that controls coat colour. AgRP is approximately 25% identical to ASIP. The murine homologue of AgRP is made up of 131 amino acids and shares 81% amino acid identity with the human protein. Biochemical studies indicate AgRP is very stable to thermal denaturation and acid degradation. Its secondary structure consists mainly of random coils and β-sheets. AgRP is mapped to human chromosome 16q22 and mouse chromosome 8D1-D2.
Read more about this topic: Agouti-related Peptide
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