AFX may stand for:
- AFX News Limited, a London financial news agency
- Animation Framework eXtension, a model for representing 3D Graphics content defined in MPEG-4 Part 16
- Aphex Twin (born 1971), electronic musician
- Application Framework eXtensions, a Microsoft programming library
- slot car, Aurora Plastics Corporation
- A replacement for the A-6 Intruder, developed by the United States Navy and United States Air Force (canceled in 1991)