Potential Therapeutic Interventions
AGEs are the subject of ongoing research. There are three therapeutic approaches: preventing the formation of AGEs, breaking AGE crosslinks after they are formed, and preventing negative effects of AGEs.
Compounds that are thought to inhibit AGE formation (at least in vitro) include: benfotiamine, pyridoxamine, alpha-lipoic acid, taurine, pimagedine, aspirin, carnosine, metformin, pioglitazone, and pentoxifylline.
Compounds that may prevent negative effects of AGEs, at least in vitro, include: resveratrol.
Compounds that are thought to break some existing AGE crosslinks include: Alagebrium (and related compounds ALT-462; ALT-486; ALT-946); N-phenacyl thiazolium bromide
However, there is no agent known that can break down the most common AGE, glucosepane, which appears 10 to 1000 times more commonly in human tissue than any other cross-linking AGE.
Read more about this topic: Advanced Glycation End-product
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