Tissue Distribution and Function
The 5-HT1B receptor acts on the CNS, where it induces presynaptic inhibition and behavioural effects. It also has vascular effects, such as pulmonary vasoconstriction.
Blocking the 5-HT1B receptor decreases the number of osteoblasts, bone mass, and the bone formation rate.
5-HT1B receptors are present in many parts of the human brain. The highest concentrations are found in the basal ganglia, striatum and the frontal cortex. The function of the receptor differs between the areas: in the frontal cortex it is believed to act as a terminal receptor, inhibiting the release of dopamine. In the striatum and the basal ganglia, the 5-HT1B receptor is thought to act as an autoreceptor, inhibiting the release of serotonin.
Knockout mice lacking the 5-HT1B gene have shown an increase of aggression and a higher preference for alcohol.
Read more about this topic: 5-HT1B Receptor
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