Schedule
| Date | Time | Opponent# | Rank# | Site | TV | Result | Attendance | |
|---|---|---|---|---|---|---|---|---|
| September 2 | 3:30 PM | Northern Illinois* | #1 | Ohio Stadium • Columbus, OH | ABC | W 35–12 | 103,896 | |
| September 9 | 8:00 PM | at #2 Texas* | #1 | Darrell K Royal–Texas Memorial Stadium • Austin, TX | ABC | W 24–7 | 89,422 | |
| September 16 | 12:00 PM | Cincinnati* | #1 | Ohio Stadium • Columbus, OH | ESPN+ | W 37–7 | 105,037 | |
| September 23 | 3:30 PM | Penn State | #1 | Ohio Stadium • Columbus, OH | ABC | W 28–6 | 105,266 | |
| September 30 | 8:00 PM | at #13 Iowa | #1 | Kinnick Stadium • Iowa City, IA | ABC | W 38–17 | 70,585 | |
| October 7 | 3:30 PM | Bowling Green* | #1 | Ohio Stadium • Columbus, OH | ESPN+ | W 35–7 | 105,057 | |
| October 14 | 3:30 PM | at Michigan State | #1 | Spartan Stadium • East Lansing, MI | ABC | W 38–7 | 73,498 | |
| October 21 | 12:00 PM | Indiana | #1 | Ohio Stadium • Columbus, OH | ESPNU | W 44–3 | 105,267 | |
| October 28 | 3:30 PM | Minnesota | #1 | Ohio Stadium • Columbus, OH | ABC | W 44–0 | 105,443 | |
| November 4 | 3:30 PM | at Illinois | #1 | Memorial Stadium • Champaign, IL | ESPN2 | W 17–10 | 53,351 | |
| November 11 | 3:30 PM | at Northwestern | #1 | Ryan Field • Evanston, IL | ABC | W 54–10 | 47,130 | |
| November 18 | 3:30 PM | #2 Michigan | #1 | Ohio Stadium • Columbus, OH (Game of the Century) | ABC | W 42–39 | 105,708 | |
| January 8 | 8:00 PM | vs. #2 Florida* | #1 | University of Phoenix Stadium • Glendale, AZ (BCS Championship) | FOX | L 14–41 | 74,628 | |
Read more about this topic: 2006 Ohio State Buckeyes Football Team