The 2005 National League Division Series (NLDS), the opening round of the 2005 National League playoffs, began on Tuesday, October 4, and ended on Sunday, October 9, with the champions of the three NL divisions—along with a "wild card" team—participating in two best-of-five series. They were:
- (1) St. Louis Cardinals (Central Division champions, 100–62) vs. (3) San Diego Padres (Western Division champions, 82–80): Cardinals win series, 3–0.
- (2) Atlanta Braves (Eastern Division champions, 90–72) vs. (4) Houston Astros (Wild Card, 89–73): Astros win series, 3–1.
The higher seed (in parentheses) had the home field advantage, which was determined by playing record. Although the team with the best record was normally intended to play the wild card team, the Cardinals played the Padres, rather than the wild card Astros, because the Cardinals and Astros are in the same division.
The Cardinals and Astros went on to meet in the NL Championship Series (NLCS). The Astros became the National League champion, and lost to the American League champion Chicago White Sox in the 2005 World Series.
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Rode the six hundred.
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