The 2001 Major League Baseball All-Star Game was the 72nd playing of the midsummer classic between the all-stars of the American League (AL) and National League (NL), the two leagues comprising Major League Baseball. The game was held on July 10, 2001 at Safeco Field in Seattle, Washington, home of the Seattle Mariners of the American League. The American League defeated the National League, 4–1. This was Cal Ripken, Jr.'s 19th and final All-Star Game. It was also the final All-Star Game for San Diego Padres legendary rightfielder Tony Gwynn.
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