Surname
- Caleb Southern, American music producer
- Edwin Southern, molecular biologist
- Eileen Southern, American musicologist
- Jeri Southern, American jazz pianist and singer
- Keith Southern, English association football player for Blackpool F.C.
- Richard Southern (theatre designer) (1903–1989), British theatre designer
- R. W. Southern (1912–2001), British medieval historian
- Sarah Southern, British businesswoman and former Conservative Party official
- Steve Southern, Australian professional rugby player
- Terry Southern, American writer
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