SMT may refer to:
- Satisfiability Modulo Theories
- Statistical machine translation
- Scottish Mortgage Investment Trust PLC (London Stock Exchange code SMT)
- Scottish Motor Traction, a former bus company in Scotland
- Seismic Micro-Technology, SMT Kingdom software integrates geological data with seismic interpretation functionality
- Sequential manual transmission
- Shanghai Maglev Train
- Shin Megami Tensei, a video game franchise
- Shin Megami Tensei, a video game developed and published by Atlus
- Smt., abbreviation for Shrimati, an Indian feminine honorific
- Simple motor tic
- Simultaneous multithreading
- Society for Music Theory
- Staatliches Museum für Tierkunde Dresden, Dresden Natural History Museum
- Strongly minimal theory
- Novell's Subscription Management Tool
- Sulfamethazine, an antibiotic whose abbreviations include SMT
- Surface-mount technology
- Heinrich Hertz Submillimeter Telescope
- Urban-type settlement (uk: selyshche mis'koho typu), in the former Soviet Union
- Sandman Mystery Theatre, a 1990s comic book devoted to the character of Wesley Dodds, the Golden-Age Sandman
- San Miguel de Tucumán, capital city of Tucumán province, Argentina