Sisko could refer to the following fictional characters from the television series, Star Trek: Deep Space Nine:
- Benjamin Sisko
- Jake Sisko
- Jennifer Sisko
- Joseph Sisko
Sisko may also refer to Sisqó, an R&B performer and the lead singer of Dru Hill
Sisko could refer to the following fictional characters from the television series, Star Trek: Deep Space Nine:
Sisko may also refer to Sisqó, an R&B performer and the lead singer of Dru Hill