Rabies Virus - Evolution

Evolution

All extant rabies viruses appear to have evolved within the last 1500 years. Consequently, the emergence of rabies may have been contemporaneous with the extreme weather events of 535–536 and/or the eruption of Krakatoa.

There are seven genotypes of rabies virus. In Eurasia cases are due to three of these - genotype 1 (classical rabies) and to a lesser extent genotypes 5 and 6 (European bat lyssaviruses type-1 and -2). Genotype 1 evolved in Europe in the 17th century and spread to Asia, Africa and the Americas as a result of European exploration and colonization.

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