Pisani is an Italian surname. Notable people with the surname include:
- Alfred Pisani (born 1939), Maltese hotelier
- Alvise Pisani, Doge of Venice
- André du Pisani, Namibian political scientist
- Andrea Pisani
- Bob Pisani, news correspondent for the financial news network CNBC
- Carmelo Borg Pisani (1915—1942), Maltese nationalist and Fascist
- Elizabeth Pisani, HIV Epidemiologist
- Fernando Pisani (born 1976), Canadian professional ice hockey winger
- Francesco Pisani, Italian Cardinal
- Joseph Pisani (born 1971), American artist, abstract painter, and designer, living in Switzerland
- Joseph H. Pisani, (born 1938 New Rochelle NY) American painter/conservator, living in Virginia USA
- Maria Adeodata Pisani, Maltese Saint
- Vettor Pisani (died 1380), Venetian admiral
- Vittore Pisani (1899—1990), Italian linguist
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