Presenilins-associated rhomboid-like protein, mitochondrial is a protein that in humans is encoded by the PARL gene. It is a member of the rhomboid family of intramembrane serine proteases.
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.