Xe or XE may refer to:
- Xenon, a chemical element
- XE.com, a currency and foreign exchange rate website
- Xpress Engine, an open source Content Management System
- Chi Epsilon (XE), a national civil engineering honor society
- ExpressJet Airlines IATA code
- XE series home computers of the Atari 8-bit family (including the 65XE, 130XE and 800XE)
- Academi, a private military company formerly known as Xe Services and Blackwater Worldwide
- Xe!, a typical Valencian interjection
- XE, a common Japanese abbreviation for Christmas Eve
- an invented gender-neutral pronoun
- XE Delphi, Embarcadero Delphi
- A company formerly known as Blackwater Worldwide and now known as Academi