Morillo is a common Spanish surname and might refer to:
- Erick Morillo (b. 1971), Colombian-American DJ
- Juan Morillo (athlete) (b. 1972), Venezuelan sprinter
- Juan Morillo (baseball) (b. 1983), Dominican Republic baseball pitcher
- Pablo Morillo (1775 - 1837), Spanish general
- Roberto García Morillo (1911–2003), Argentine composer