Methodius or Methodios may refer to:
- Methodius of Olympus (d. 311), Christian bishop, church father, and martyr
- Methodios I of Constantinople (c. 790-847), patriarch of Constantinople
- Saint Methodius of Thessaloniki (826-885), Byzantine Greek archbishop of Great Moravia and scholar
- Methodios Anthrakites (1660–1736), Greek scholar, priest and director of the Gioumeios and Epiphaneios Schools in Ioannina
- Metodyj Trochanovskij (1885–1947), Polish activist
- Metropolitan Methodios (Tournas) of Boston (born 1946), the spiritual leader of the Greek Orthodox Metropolis of Boston
- Methodius Buslaev, fictional character from Dmitri Yemets's book series
- Methodius (Berat), Berat's archbishop, who in 1743 renovated the Ardenica Monastery
- St. Methodios Faith and Heritage Center, a camp run by the Greek Orthodox Metropolis of Boston located in the town of Hopkinton, New Hampshire, United States