HMD can refer to:
Biochemistry:
- H2-forming methylene-tetrahydromethanopterin dehydrogenase
Medicine:
- Heavy Metal Detox (HMD)
- Hepatic microvascular dysplasia
- Hyaline membrane disease, a previous name for infant respiratory distress syndrome, a common developmental lung surfactant deficiency
Places:
- Hammond (Amtrak station), Louisiana, United States; Amtrak station code
- Heard Island and McDonald Islands, ISO 3166 country code
Technology:
- Head-mounted display
- Helmet mounted display