Discovery
While at the NIH, Venter learned of a technique for rapidly identifying all of the mRNAs present in a cell and began to use it to identify human brain genes. The short cDNA sequence fragments discovered by this method are called expressed sequence tags (ESTs), a name coined by Anthony Kerlavage at The Institute for Genomic Research. The NIH initially led an effort to patent these gene fragments, in which Venter coincidentally and controversially became involved. The NIH later withdrew the patent applications, following public outcry. Subsequent court cases declared that ESTs were not directly patentable.
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