Genetic Diseases Caused By Defects in Central Tolerance
Genetic defects in central tolerance can lead to autoimmunity.
- Autoimmune Polyendocrinopathy Syndrome Type I is caused by mutations in the human gene AIRE. This leads to a lack of expression of peripheral antigens in the thymus, and hence a lack of negative selection towards key peripheral proteins such as insulin. Multiple autoimmune symptoms result.
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Famous quotes containing the words genetic, diseases, caused, defects, central and/or tolerance:
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“Arrogance, pedantry, and dogmatism ... the occupational diseases of those who spend their lives directing the intellects of the young.”
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That caused the Lord of bliss
To bear the dreadful curse for my soul”
—Unknown. “What Wondrous Love is this!” L. 3-5, Dupuy’s Hymns and Spiritual Songs (1811)
“A fool may be a dangerous customer, but the fact of his having such a vulnerable top-end turns danger into a first-rate sport; and whatever defects the old administration in Russia had, it must be conceded that it possessed one outstanding virtue—a lack of brains.”
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“Et in Arcadia ego.
[I too am in Arcadia.]”
—Anonymous, Anonymous.
Tomb inscription, appearing in classical paintings by Guercino and Poussin, among others. The words probably mean that even the most ideal earthly lives are mortal. Arcadia, a mountainous region in the central Peloponnese, Greece, was the rustic abode of Pan, depicted in literature and art as a land of innocence and ease, and was the title of Sir Philip Sidney’s pastoral romance (1590)
“For all the injustices in our past and our present, we have to believe that in the free exchange of ideas, justice will prevail over injustice, tolerance over intolerance and progress over reaction.”
—Hillary Rodham Clinton (b. 1947)