Central Tolerance

Central tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self. The concept of central tolerance was proposed in 1959 by Joshua Lederberg, as part of his general theory of immunity and tolerance, and is often mistakenly attributed to MacFarlane Burnet. Lederberg hypothesized that it is the age of the lymphocyte that defines whether an antigen that is encountered will induce tolerance, with immature lymphocytes being tolerance sensitive. Lederberg's theory that self-tolerance is 'learned' during lymphocyte development was a major conceptual contribution to immunology, and it was experimentally substantiated in the late 1980s when tools to analyze lymphocyte development became available. Central tolerance is distinct from periphery tolerance in that it occurs while cells are still present in the primary lymphoid organs (thymus and bone-marrow), prior to export into the periphery, while peripheral tolerance is generated after the cells reach the periphery. Regulatory T cells can be considered both central tolerance and peripheral tolerance mechanisms, as they can be generated from self(or foreign)-reactive T cells in the thymus during T cell differentiation, but they exert their immune suppression in the periphery on other self(or foreign)-reactive T cells.

Read more about Central ToleranceRequirement For Central Tolerance, Genetic Diseases Caused By Defects in Central Tolerance

Other articles related to "central tolerance":

Genetic Diseases Caused By Defects in Central Tolerance
... Genetic defects in central tolerance can lead to autoimmunity ... Autoimmune Polyendocrinopathy Syndrome Type I is caused by mutations in the human gene AIRE ...
Immune Tolerance - Central Tolerance
... Central tolerance occurs during lymphocyte development and operates in the thymus and bone marrow ... In the case of T cell central tolerance, additional sources of antigen are made available in the thymus by the action of the transcription factor AIRE ...

Famous quotes containing the words tolerance and/or central:

    For all the injustices in our past and our present, we have to believe that in the free exchange of ideas, justice will prevail over injustice, tolerance over intolerance and progress over reaction.
    Hillary Rodham Clinton (b. 1947)

    The best laws cannot make a constitution work in spite of morals; morals can turn the worst laws to advantage. That is a commonplace truth, but one to which my studies are always bringing me back. It is the central point in my conception. I see it at the end of all my reflections.
    Alexis de Tocqueville (1805–1859)