Central Tolerance

Central tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self. The concept of central tolerance was proposed in 1959 by Joshua Lederberg, as part of his general theory of immunity and tolerance, and is often mistakenly attributed to MacFarlane Burnet. Lederberg hypothesized that it is the age of the lymphocyte that defines whether an antigen that is encountered will induce tolerance, with immature lymphocytes being tolerance sensitive. Lederberg's theory that self-tolerance is 'learned' during lymphocyte development was a major conceptual contribution to immunology, and it was experimentally substantiated in the late 1980s when tools to analyze lymphocyte development became available. Central tolerance is distinct from periphery tolerance in that it occurs while cells are still present in the primary lymphoid organs (thymus and bone-marrow), prior to export into the periphery, while peripheral tolerance is generated after the cells reach the periphery. Regulatory T cells can be considered both central tolerance and peripheral tolerance mechanisms, as they can be generated from self(or foreign)-reactive T cells in the thymus during T cell differentiation, but they exert their immune suppression in the periphery on other self(or foreign)-reactive T cells.

Read more about Central ToleranceRequirement For Central Tolerance, Genetic Diseases Caused By Defects in Central Tolerance

Other articles related to "central tolerance":

Immune Tolerance - Central Tolerance
... Central tolerance occurs during lymphocyte development and operates in the thymus and bone marrow ... In the case of T cell central tolerance, additional sources of antigen are made available in the thymus by the action of the transcription factor AIRE ...
Genetic Diseases Caused By Defects in Central Tolerance
... Genetic defects in central tolerance can lead to autoimmunity ... Autoimmune Polyendocrinopathy Syndrome Type I is caused by mutations in the human gene AIRE ...

Famous quotes containing the words tolerance and/or central:

    Advocating the mere tolerance of difference between women is the grossest reformism. It is a total denial of the creative function of difference in our lives. Difference must be not merely tolerated, but seen as a fund of necessary polarities between which our creativity can spark like a dialectic.
    Audre Lorde (1934–1992)

    When life has been well spent, age is a loss of what it can well spare,—muscular strength, organic instincts, gross bulk, and works that belong to these. But the central wisdom, which was old in infancy, is young in fourscore years, and dropping off obstructions, leaves in happy subjects the mind purified and wise.
    Ralph Waldo Emerson (1803–1882)